Anti-LGR5 antibody [OTI2A2],Abcam,AB273092
Product Specifications Anti-LGR5 antibody [OTI2A2] (ab273092) is a mouse monoclonal antibody and is validated for use in Flow Cyt, ICC/IF in human samples. Anti-LGR5 antibody [OTI2A2] (ab273092) specifically detects LGR5 (UniProt ID: O75473; Molecular weight: 98kDa) and is sold in 100 µg selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-LGR5 antibody [OTI2A2] (ab273092) has high sensitivity and specificity.
Host
Mouse
Reactivity
Human
Application
ICC/IF, Flow Cyt
Platform ID
BAB496128624
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. See full target information LGR5
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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