Anti-LMBRD1 antibody,Abcam,AB105419

Target data Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors (PubMed : 19136951). Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome (PubMed : 27456980). Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (PubMed : 25535791). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity).. Isoform 3. (Microbial infection) May play a role in the assembly of hepatitis delta virus (HDV). See full target information LMBRD1