Anti-LRP1 antibody [EPR3724],Abcam,AB92544
Anti-LRP1 antibody [EPR3724] (ab92544) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, IP, WB in human, mouse, pig, rat samples. Anti-LRP1 antibody [EPR3724] (ab92544) has been cited over 194 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality manufacturing and validation processes ensure Anti-LRP1 antibody [EPR3724] (ab92544) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-LRP1 antibody [EPR3724] (ab92544) has been confirmed by testing in knockout samples. Anti-LRP1 antibody [EPR3724] (ab92544) has 9 independent reviews from customers. Anti-LRP1 antibody [EPR3724] (ab92544) specifically detects LRP1 (UniProt ID: Q07954; Molecular weight: 503kDa) and is sold in a convenient trial size to enable initial testing (20 uL) and larger sizes for subsequent scaling up experiments (100 uL and 1 mL). Conjugation-ready, carrier free format available for antibody clone EPR3724 - ab215997 . Antibody clone EPR3724 is also available pre-conjugated to a variety of labels for your convenience - HRP, APC, PE, Alexa Fluor® 568, Alexa Fluor® 555 ( ab195569 , ab31885 , ab31941, ab312965 , ab313174 ). Low-density lipoprotein receptor-related protein (LRP) is a versatile receptor that plays a crucial role in various physiological functions, including lipid metabolism, endocytosis, and cellular signaling. It is particularly important in the clearance of amyloid-beta peptides, which are linked to Alzheimer's disease (AD). Changes in LRP expression or function are associated with a range of diseases, such as cardiovascular diseases, neurodegenerative disorders like AD, and certain types of cancer. Studying LRP provides valuable insights into its role in these conditions and the underlying mechanisms, underscoring its significance in disease pathology research. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human, Pig
Application
ICC/IF, WB, IHC-P, IP, Flow Cyt (Intra)
Platform ID
BAB998977256

Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed : 11907044, PubMed : 12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed : 1702392, PubMed : 26142438). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed : 32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed : 12888553). Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (PubMed : 9252371).. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. See full target information LRP1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
- Products>Trial Size Antibodies
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