Anti-Lamin B Receptor/LBR antibody [BBmLBR 12.F8],Abcam,AB232731

What is this antibody validated in? Anti-Lamin B Receptor/LBR antibody [BBmLBR 12.F8] (ab232731) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse samples. What is the molecular weight of Lamin B Receptor/LBR? Anti-Lamin B Receptor/LBR [BBmLBR 12.F8] (ab232731) specifically detects a band for Lamin B Receptor/LBR (UniProt: Q3U9G9) at a molecular weight of 71kDa. Specificity confirmed The specificity of Anti-Lamin B Receptor/LBR antibody [BBmLBR 12.F8] (ab232731) has been confirmed by Western blot testing in Lbr Knockout HEK-293 cells. Other related products We have a range of other formats of antibody clone [BBmLBR 12.F8] also available for your convenience: ab232731, Carrier free - ab269576 Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected]

Host

Mouse

Reactivity

Mouse, Human

Application

WB, ICC/IF, IHC-P

Platform ID

BAB993479896

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Lamin B Receptor/LBR antibody [BBmLBR 12.F8]
Cat. No.AB232731
HostMouse
IsotypeIgG2b
ReactivityMouse, Human
ApplicationWB, ICC/IF, IHC-P
ClonalityMonoclonal
Clone NumberBBmLBR 12.F8
Concentration1 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.02% Sodium azide Constituents: PBS, 6.97% L-Arginine
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed : 18785926). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (PubMed : 22140257). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (PubMed : 22140257). Anchors the lamina and the heterochromatin to the inner nuclear membrane (By similarity). See full target information Lbr

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