Anti-Liver Arginase antibody [EPR6672(B)],Abcam,AB133543
What is this antibody validated in? Anti-Liver Arginase antibody [EPR6672(B)] (ab133543) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P) in Human samples. What is the molecular weight of Liver Arginase? Anti-Liver Arginase [EPR6672(B)] (ab133543) specifically detects a band for Liver Arginase (UniProt: P05089) at a molecular weight of 35kDa. Trusted by the scientific community Anti-Liver Arginase [EPR6672(B)] (ab133543) was first used in a scientific publication in 2012 and has been cited over 10 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-Liver Arginase antibody [EPR6672(B)] (ab133543) has been confirmed by Western blot testing in ARG1 Knockout HepG2 cell line, ab281603 . Other related products We have a range of other formats of antibody clone [EPR6672(B)] also available for your convenience: ab133543, HRP - ab195510 , Carrier free - ab211961 , Alexa Fluor® 488 - ab275992 , Alexa Fluor® 647 - ab277922 , Alexa Fluor® 594 - ab277930 , Alexa Fluor® 555 - ab280848 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human
Application
IP, IHC-P, WB
Platform ID
BAB497627904
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.. Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (PubMed : 15546957, PubMed : 16709924, PubMed : 19380772). In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (By similarity). In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure. See full target information ARG1
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