Anti-MADH7/SMAD7 antibody,Abcam,AB244424

Host

Rabbit

Reactivity

Human

Application

ICC/IF, IHC-P

Platform ID

BAB252000804

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-MADH7/SMAD7 antibody
Cat. No.AB244424
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationICC/IF, IHC-P
ClonalityPolyclonal
Concentration0.3 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human SMAD7 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access (PubMed : 21791611). Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. See full target information SMAD7

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