Anti-MAP1 antibody,Abcam,AB115511

Target data Retrotransposon-derived protein that forms virion-like capsids (By similarity). Acts as an effector of BAX during apoptosis : enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis (PubMed : 11060313, PubMed : 16199525). Required for death receptor-dependent apoptosis (PubMed : 11060313). When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (PubMed : 15949439). Also promotes autophagy : promotes phagophore closure via association with ATG8 proteins (PubMed : 33783314). Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1 : interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex (PubMed : 33393215). See full target information MOAP1