Anti-MAP1B antibody,Abcam,AB224115

Host

Rabbit

Reactivity

Human

Application

IHC-P, ICC/IF, WB

Platform ID

BAB628087782

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-MAP1B antibody
Cat. No.AB224115
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIHC-P, ICC/IF, WB
ClonalityPolyclonal
Concentration0.1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human MAP1B aa 1300-1500. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed : 33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. See full target information MAP1B

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