Anti-MAdCAM1 antibody [AP-MAB0842],Abcam,AB80680

Endotoxin Level: Extremely low level of LPS (< 0.002EU/μg IgG). ab80680 was produced by in vitro culture, from a hybridoma (mouse myeloma fused with spleen cells from an immunized rat). ab80680 is useful for reducing T cell mediated inflammation in gastrointestinal diseases.

Host

Rat

Reactivity

Mouse

Application

IHC-Fr, FuncS (Neut/Block), IHC-P, Flow Cyt, IP

Platform ID

BAB501925840

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-MAdCAM1 antibody [AP-MAB0842]
Cat. No.AB80680
HostRat
IsotypeIgG2
ReactivityMouse
ApplicationIHC-Fr, FuncS (Neut/Block), IHC-P, Flow Cyt, IP
ClonalityMonoclonal
Clone NumberAP-MAB0842
Concentration1 mg/mL Batch dependent concentration
ImmunogenCell preparation containing Madcam1 protein. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationConstituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Both isoform 1 and isoform 2 can adhere to integrin alpha-4/beta-7. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding. See full target information Madcam1

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