Anti-MBD2 + MBD3 antibody [106B691],Abcam,AB45027
The theoretical molecular weight of human MBD2 (411 amino acids) is 45 kD and human MBD3 (291 amino acids) is 33 kD.
Host
Mouse
Reactivity
Human
Application
IHC-P, ICC/IF, WB, Flow Cyt (Intra)
Platform ID
BAB129736990
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed : 9774669). Binds hemimethylated DNA as well (PubMed : 10947852, PubMed : 24307175). Recruits histone deacetylases and DNA methyltransferases to chromatin (PubMed : 10471499, PubMed : 10947852). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed : 16428440, PubMed : 28977666). Acts as a transcriptional repressor and plays a role in gene silencing (PubMed : 10471499, PubMed : 10947852, PubMed : 16415179). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (PubMed : 16415179). May enhance the activation of some unmethylated cAMP-responsive promoters (PubMed : 12665568). See full target information MBD2 Additional targets MBD3
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
Please provide the required information below so that we can quickly source your products.