Anti-MCM2 antibody [EPR4120],Abcam,AB108935
What is this antibody validated in? Anti-MCM2 antibody [EPR4120] (ab108935) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples. What is the molecular weight of MCM2? Anti-MCM2 [EPR4120] (ab108935) specifically detects a band for MCM2 (UniProt: P49736) at a molecular weight of 102kDa. Trusted by the scientific community Anti-MCM2 [EPR4120] (ab108935) was first used in a scientific publication in 2011 and has been cited over 20 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Other related products We have a range of other formats of antibody clone [EPR4120] also available for your convenience: ab108935, Alexa Fluor® 488 - ab223402 , Alexa Fluor® 647 - ab223403 , Carrier free - ab226044 , PE - ab303154 , APC - ab303155 , HRP - ab303156 , Alkaline Phosphatase - ab308707 , Alexa Fluor® 594 - ab310426 , Alexa Fluor® 555 - ab311952 , Alexa Fluor® 568 - ab312425 , Alexa Fluor® 750 - ab320919 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
IP, Flow Cyt (Intra), IHC-P, ICC/IF, WB
Platform ID
BAB817830455
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed : 32453425, PubMed : 34694004, PubMed : 34700328, PubMed : 35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed : 32453425). Required for the entry in S phase and for cell division (PubMed : 8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed : 26196677). See full target information MCM2
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