Anti-MDMX/MDM4 antibody,Abcam,AB244366
Host
Rabbit
Reactivity
Human
Application
IHC-P
Platform ID
BAB506523632
Abcam
Contact
Tel: +44 (0)1223 696000
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Product Specifications
Scientific Background
Specifications
NameAnti-MDMX/MDM4 antibody
Cat. No.AB244366
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIHC-P
ClonalityPolyclonal
Concentration0.3 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human MDM4 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only
Scientific Background
Target data Along with MDM2, contributes to TP53 regulation (PubMed : 32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. See full target information MDM4
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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