Anti-MEK2 antibody [OTI1A2],Abcam,AB140372

The clone number has been updated from 1A2 to OTI1A2, both clone numbers name the same clone.

Host

Mouse

Reactivity

Mouse, Rat, Dog, Human, African green monkey

Application

IHC-P, WB, ICC/IF

Platform ID

BAB257398212

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-MEK2 antibody [OTI1A2]
Cat. No.AB140372
HostMouse
IsotypeIgG1
ReactivityMouse, Rat, Dog, Human, African green monkey
ApplicationIHC-P, WB, ICC/IF
ClonalityMonoclonal
Clone NumberOTI1A2
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Full Length Protein corresponding to Human MAP2K2.
PurityAffinity purification
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed : 29433126). See full target information MAP2K2

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