Anti-MERTK antibody [Y323],Abcam,AB52968
What is this antibody validated in? Anti-MERTK antibody [Y323] (ab52968) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr) in Human samples. Trusted by the scientific community Anti-MERTK [Y323] (ab52968) was first used in a scientific publication in 2007 and has been cited over 60 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-MERTK antibody [Y323] (ab52968) has been confirmed by Western blot testing in MERTK Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [Y323] also available for your convenience: ab52968, Carrier free - ab176887 , HRP - ab197643 , Carrier free - ab271851 , Alexa Fluor® 647 - ab305049 , Alexa Fluor® 555 - ab305368 , Alexa Fluor® 488 - ab307385 , Alexa Fluor® 594 - ab311784 , Alexa Fluor® 568 - ab313065 , Alexa Fluor® 750 - ab321677 Species reactivity Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human
Application
WB, IHC-P, IP, IHC-Fr
Platform ID
BAB258197828
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment (PubMed : 32640697). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. See full target information MERTK
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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