Anti-MICB antibody [B-D54] - BSA and Azide free,Abcam,AB270760

Host

Mouse

Reactivity

Human

Application

Flow Cyt

Platform ID

BAB760146892

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-MICB antibody [B-D54] - BSA and Azide free
Cat. No.AB270760
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationFlow Cyt
ClonalityMonoclonal
Clone NumberB-D54
ImmunogenRecombinant Fragment Protein within Human MICB aa 1-300. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.3 - 7.5 Constituents: PBS
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8+ alphabeta T-cells (PubMed : 11491531, PubMed : 11777960). Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production. See full target information MICB

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