Anti-MIF antibody [BLR141J] - BSA free,Abcam,AB314057

REACH authorisation Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances. It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.

Host

Rabbit

Reactivity

Human

Application

IHC-P, ICC, WB, Flow Cyt

Platform ID

BAB135334302

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-MIF antibody [BLR141J] - BSA free
Cat. No.AB314057
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIHC-P, ICC, WB, Flow Cyt
ClonalityMonoclonal
Clone NumberBLR141J
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human MIF aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.8 - 8.6 Preservative: 0.09% Sodium azide Constituents: 98% Borate buffered saline
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens (PubMed : 15908412, PubMed : 17443469, PubMed : 23776208). The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense (PubMed : 15908412, PubMed : 17443469, PubMed : 23776208). Counteracts the anti-inflammatory activity of glucocorticoids (PubMed : 15908412, PubMed : 17443469, PubMed : 23776208). Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known (PubMed : 11439086, PubMed : 17526494). It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (PubMed : 11439086, PubMed : 17526494). See full target information MIF

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