Anti-MMP14 antibody [EP1264Y],Abcam,AB51074

Product Specifications Anti-MMP14 antibody [EP1264Y] (ab51074) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt, ICC/IF, IHC-P, IP, WB in human, mouse, rat samples. Anti-MMP14 antibody [EP1264Y] (ab51074) specifically detects MMP14 (UniProt ID: P50281; Molecular weight: 54kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-MMP14 antibody [EP1264Y] (ab51074) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-MMP14 antibody [EP1264Y] (ab51074) has been confirmed by testing in knockout samples. Anti-MMP14 antibody [EP1264Y] (ab51074) has been cited over 175 times in peer reviewed journals and is trusted by the scientific community. Anti-MMP14 antibody [EP1264Y] (ab51074) has 20 independent reviews from customers. Related Products Antibody clone EP1264Y is also available pre-conjugated to a variety of labels for your convenience - HRP, Alexa Fluor® 647, Alexa Fluor® 555, Alexa Fluor® 488, PE ( ab194242 , ab300749 , ab302548 , ab302582 , ab303602 ). Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

Flow Cyt, WB, IP, ICC/IF, IHC-P

Platform ID

BAB637083462

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-MMP14 antibody [EP1264Y]
Cat. No.AB51074
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationFlow Cyt, WB, IP, ICC/IF, IHC-P
ClonalityMonoclonal
Clone NumberEP1264Y
Concentration0.163 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Endopeptidase that degrades various components of the extracellular matrix such as collagen (PubMed : 8015608). Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration (PubMed : 22065321, PubMed : 8015608). Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed : 12714657, PubMed : 22065321). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed : 20837484). Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1 (PubMed : 21572390). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed : 22330140). Acts as a negative regulator of the GDF15-GFRAL aversive response by mediating cleavage and inactivation of GFRAL (PubMed : 35177851). See full target information MMP14

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