Anti-MMP14 antibody [EP1264Y] - BSA and Azide free,Abcam,AB271840

The mouse and rat recommendation is based on the WB results. This antibody may not be suitable for IHC with mouse or rat samples. ab271840 is the carrier-free version of ab51074 . Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Conjugation ready Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold. Compatibility This product is compatible with the Maxpar ® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar ® is a trademark of Fluidigm Canada Inc.

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

Flow Cyt, ICC/IF, WB, IHC-P, IP

Platform ID

BAB949589709

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-MMP14 antibody [EP1264Y] - BSA and Azide free
Cat. No.AB271840
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationFlow Cyt, ICC/IF, WB, IHC-P, IP
ClonalityMonoclonal
Clone NumberEP1264Y
Concentration1.067 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Constituents: PBS
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Endopeptidase that degrades various components of the extracellular matrix such as collagen (PubMed : 8015608). Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration (PubMed : 22065321, PubMed : 8015608). Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed : 12714657, PubMed : 22065321). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed : 20837484). Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1 (PubMed : 21572390). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed : 22330140). Acts as a negative regulator of the GDF15-GFRAL aversive response by mediating cleavage and inactivation of GFRAL (PubMed : 35177851). See full target information MMP14

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