Anti-MMS22L (C6ORF167) antibody [EPR13654] - BSA and Azide free,Abcam,AB250307
ab250307 is the carrier-free version of ab181047 . Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Conjugation ready Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold. Compatibility This product is compatible with the Maxpar ® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar ® is a trademark of Fluidigm Canada Inc.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Application
WB, Flow Cyt (Intra), IP
Platform ID
BAB387758138

Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks (PubMed : 21055983, PubMed : 21055984, PubMed : 21055985, PubMed : 21113133, PubMed : 26527279, PubMed : 27338793, PubMed : 29478807). The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication (PubMed : 21055983, PubMed : 21055984, PubMed : 21055985, PubMed : 27797818). It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA) : the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs (PubMed : 21055983, PubMed : 21055984, PubMed : 21055985, PubMed : 29478807). Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination (PubMed : 27797818, PubMed : 29478807). Within the complex, MMS22L acts by binding ssDNA (PubMed : 27797818). See full target information MMS22L
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