Anti-MRP2 antibody [M2 III-6],Abcam,AB3373
What is this antibody validated in? Anti-MRP2 antibody [M2 III-6] (ab3373) is a mouse monoclonal antibody and is validated for use in Western Blot (WB) in Human samples. What is the molecular weight of MRP2? Anti-MRP2 [M2 III-6] (ab3373) specifically detects a band for MRP2 (UniProt: Q92887) at a molecular weight of 174kDa. Trusted by the scientific community Anti-MRP2 [M2 III-6] (ab3373) was first used in a scientific publication in 2003 and has been cited over 80 times in peer-reviewed journals. Reviewed by scientists Anti-MRP2 [M2 III-6] (ab3373) has over 5 independent reviews from customers. Specificity confirmed The specificity of Anti-MRP2 antibody [M2 III-6] (ab3373) has been confirmed by Western blot testing in ABCC2 Knockout A549 cells.
Host
Mouse
Reactivity
Human
Application
WB
Platform ID
BAB139132478
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed : 10220572, PubMed : 10421658, PubMed : 11500505, PubMed : 16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed : 10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed : 11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed : 16332456). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed : 10220572, PubMed : 11500505, PubMed : 12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed : 10220572, PubMed : 11500505). See full target information ABCC2
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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