Anti-MRP4 antibody [EPR20403],Abcam,AB233382

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Human

Application

IP, ICC/IF, WB, IHC-P

Platform ID

BAB639182454

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-MRP4 antibody [EPR20403]
Cat. No.AB233382
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIP, ICC/IF, WB, IHC-P
ClonalityMonoclonal
Clone NumberEPR20403
Concentration0.454 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed : 11856762, PubMed : 12523936, PubMed : 12835412, PubMed : 12883481, PubMed : 15364914, PubMed : 15454390, PubMed : 16282361, PubMed : 17959747, PubMed : 18300232, PubMed : 26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed : 17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed : 12523936, PubMed : 12883481, PubMed : 16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed : 11856762, PubMed : 12105214, PubMed : 15454390, PubMed : 17344354, PubMed : 18300232). Confers resistance to anticancer agents such as methotrexate (PubMed : 11106685). See full target information ABCC4

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