Anti-Mannan Binding Lectin/MBL antibody [1E2],Abcam,AB23458

ab23458 reacts with human MBL both in its poltmeric conforation and as a single subunit of moleculat mass 26 kDa. Can be applied for quantitative measurement of MBL in plasma or serum.

Host

Mouse

Reactivity

Human

Application

ELISA, WB

Platform ID

BAB002875384

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Mannan Binding Lectin/MBL antibody [1E2]
Cat. No.AB23458
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationELISA, WB
ClonalityMonoclonal
Clone Number1E2
Concentration1 - 1.07 mg/mL Batch dependent concentration
ImmunogenFull Length Protein corresponding to Human MBL2. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS, 2.9% Sodium chloride
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Calcium-dependent lectin involved in innate immune defense (PubMed : 35102342). Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed : 35102342). See full target information MBL2

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