Anti-Met (c-Met) antibody [EP1454Y] - N-terminal,Abcam,AB51067
Product Specifications Anti-Met (c-Met) antibody [EP1454Y] - N-terminal (ab51067) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in I-ELISA, IHC-P, WB in human, mouse, rat samples. Anti-Met (c-Met) antibody [EP1454Y] - N-terminal (ab51067) specifically detects Met (c-Met) (UniProt ID: P08581; Molecular weight: 153kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-Met (c-Met) antibody [EP1454Y] - N-terminal (ab51067) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-Met (c-Met) antibody [EP1454Y] - N-terminal (ab51067) has been confirmed by testing in knockout samples. Anti-Met (c-Met) antibody [EP1454Y] - N-terminal (ab51067) has been cited over 113 times in peer reviewed journals and is trusted by the scientific community. Anti-Met (c-Met) antibody [EP1454Y] - N-terminal (ab51067) has 13 independent reviews from customers. Related Products Conjugation-ready, carrier free format available for antibody clone EP1454Y - ab157370 . Antibody clone EP1454Y is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, Alexa Fluor® 594, Alexa Fluor® 568, Alexa Fluor® 555, Alexa Fluor® 750, HRP ( ab311009 , ab311137 , ab311774 , ab313055 , ab313255 , ab321642 ). Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
WB, IHC-P, I-ELISA
Platform ID
BAB008472696
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation. During skeletal muscle development, it is crucial for the migration of muscle progenitor cells and for the proliferation of secondary myoblasts (By similarity). In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Also promotes differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).. (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells. See full target information MET
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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