Anti-Mitofusin 2 antibody [NIAR164],Abcam,AB124773
What is this antibody validated in? Anti-Mitofusin 2 antibody [NIAR164] (ab124773) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples. What is the molecular weight of Mitofusin 2? Anti-Mitofusin 2 [NIAR164] (ab124773) specifically detects a band for Mitofusin 2 (UniProt: O95140) at a molecular weight of 86kDa. Trusted by the scientific community Anti-Mitofusin 2 [NIAR164] (ab124773) was first used in a scientific publication in 2012 and has been cited over 80 times in peer-reviewed journals. Reviewed by scientists Anti-Mitofusin 2 [NIAR164] (ab124773) has over 5 independent reviews from customers. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-Mitofusin 2 antibody [NIAR164] (ab124773) has been confirmed by Western blot testing in MFN2 Knockout HEK-293 cells. Other related products We have a range of other formats of antibody clone [NIAR164] also available for your convenience: ab124773, Carrier free - ab219730 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
ICC/IF, IHC-P, WB
Platform ID
BAB573602683
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed : 11181170, PubMed : 11950885, PubMed : 19889647, PubMed : 26214738, PubMed : 28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed : 28114303). Overexpression induces the formation of mitochondrial networks (PubMed : 28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed : 23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed : 23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity). See full target information MFN2
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