Anti-MyD88 antibody,Abcam,AB2064
What is this antibody validated in? Anti-MyD88 antibody (ab2064) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse samples. What is the molecular weight of MyD88? Anti-MyD88 (ab2064) specifically detects a band for MyD88 (UniProt: Q99836) at a molecular weight of 33kDa. Trusted by the scientific community Anti-MyD88 (ab2064) was first used in a scientific publication in 2000 and has been cited over 140 times in peer-reviewed journals. Reviewed by scientists Anti-MyD88 (ab2064) has over 10 independent reviews from customers. Specificity confirmed The specificity of Anti-MyD88 antibody (ab2064) has been confirmed by Western blot testing in MYD88 Knockout A549 cell line, ab286715 .
Host
Rabbit
Reactivity
Human, Mouse
Application
WB, IHC-P, ICC/IF
Platform ID
BAB455536853
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed : 15361868, PubMed : 18292575, PubMed : 33718825, PubMed : 37971847). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed : 15361868, PubMed : 19506249, PubMed : 24316379). Increases IL-8 transcription (PubMed : 9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation (PubMed : 33718825). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity). See full target information MYD88
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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