Anti-MyD88 antibody [EPR590(N)],Abcam,AB133739
What is this antibody validated in? Anti-MyD88 antibody [EPR590(N)] (ab133739) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples. What is the molecular weight of MyD88? Anti-MyD88 [EPR590(N)] (ab133739) specifically detects a band for MyD88 (UniProt: Q99836) at a molecular weight of 33kDa. Trusted by the scientific community Anti-MyD88 [EPR590(N)] (ab133739) was first used in a scientific publication in 2012 and has been cited over 40 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-MyD88 antibody [EPR590(N)] (ab133739) has been confirmed by Western blot testing in MYD88 Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [EPR590(N)] also available for your convenience: ab133739, Carrier free - ab199247 , HRP - ab218705 , Alexa Fluor® 488 - ab320392 , Alexa Fluor® 647 - ab320393 , Alexa Fluor® 555 - ab320394 , Alexa Fluor® 594 - ab320395 , PE - ab320396 , APC - ab320397 , Alexa Fluor® 750 - ab321067 Species reactivity Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human
Application
IHC-P, Flow Cyt (Intra), ICC/IF, WB
Platform ID
BAB705561841
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed : 15361868, PubMed : 18292575, PubMed : 33718825, PubMed : 37971847). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed : 15361868, PubMed : 19506249, PubMed : 24316379, PubMed : 40638072). Increases IL-8 transcription (PubMed : 9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation (PubMed : 33718825). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity). See full target information MYD88
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