Anti-Myelin Basic Protein antibody [IGX3421] - Oligodendrocyte Marker,Abcam,AB209328

What is this antibody validated in? Anti-Myelin Basic Protein antibody [IGX3421] (ab209328) is a human recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF), ELISA in Human, Mouse, Rat, samples. What is the molecular weight of Myelin Basic Protein? Anti-Myelin Basic Protein [IGX3421] (ab209328) specifically detects a band for Myelin Basic Protein (UniProt: P02687) at a molecular weight of 33kDa. Trusted by the scientific community Anti-Myelin Basic Protein [IGX3421] (ab209328) was first used in a scientific publication in 2016 and has been cited over 10 times in peer-reviewed journals. Reviewed by scientists Anti-Myelin Basic Protein [IGX3421] (ab209328) has over 5 independent reviews from customers. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies.

Host

Human

Reactivity

Mouse, Rat, Human

Application

ICC, ICC/IF, WB, ELISA, IHC-P

Platform ID

BAB268193028

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Myelin Basic Protein antibody [IGX3421] - Oligodendrocyte Marker
Cat. No.AB209328
HostHuman
IsotypeIgG1
ReactivityMouse, Rat, Human
ApplicationICC, ICC/IF, WB, ELISA, IHC-P
ClonalityMonoclonal
Clone NumberIGX3421
Concentration0.468 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. See full target information MBP

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