Anti-Myeloperoxidase antibody [2C7],Abcam,AB25989

What is this antibody validated in? Anti-Myeloperoxidase antibody [2C7] (ab25989) is a mouse monoclonal antibody and is validated for use in Flow Cytometry (Flow Cyt) in Human samples. Trusted by the scientific community Anti-Myeloperoxidase [2C7] (ab25989) was first used in a scientific publication in 2005 and has been cited over 90 times in peer-reviewed journals. Reviewed by scientists Anti-Myeloperoxidase [2C7] (ab25989) has over 5 independent reviews from customers. Other related products We have a range of other formats of antibody clone [2C7] also available for your convenience: ab283263 , Carrier free - ab283284 , FITC - ab11729 , PE - ab11730

Host

Mouse

Reactivity

Human

Application

Flow Cyt

Platform ID

BAB768442908

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Myeloperoxidase antibody [2C7]
Cat. No.AB25989
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationFlow Cyt
ClonalityMonoclonal
Clone Number2C7
Concentration1 mg/mL Batch dependent concentration
ImmunogenNative Full Length Protein corresponding to Human MPO.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.09% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed : 9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed : 25698971). See full target information MPO

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