Anti-Myeloperoxidase antibody,Abcam,AB9535
Anti-Myeloperoxidase antibody (ab9535) is a rabbit polyclonal antibody and is validated for use in ICC, IHC-P in human, mouse samples. Anti-Myeloperoxidase antibody (Anti-MPO antibody) (ab9535) has been cited over 320 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Myeloperoxidase antibody (ab9535) has high sensitivity and specificity. Anti-Myeloperoxidase antibody (ab9535) has 36 independent reviews from customers. Anti-Myeloperoxidase antibody (ab9535) specifically detects Myeloperoxidase (UniProt ID: P05164; Molecular weight: 79kDa) and is sold in 500 µL selling sizes. Myeloperoxidase (MPO) is an enzyme predominantly found in neutrophils, where it plays a critical role in the immune response by producing hypochlorous acid to kill pathogens. However, MPO can also contribute to tissue damage and inflammation, and its deficiency is linked to increased susceptibility to infections, particularly fungal infections like those caused by Candida species. MPOcontributes to inflammation by producing reactive oxygen species (ROS) and hypochlorous acid (HOCl) during the immune response. This enzyme's activity is linked to various inflammatory diseases, including atherosclerosis and neuroinflammation.
Host
Rabbit
Reactivity
Human
Application
ICC, IHC-P
Platform ID
BAB955986637
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed : 9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed : 25698971). See full target information MPO
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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