Anti-N Cadherin antibody,Abcam,AB211126

Target data Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (PubMed : 12091300). Required for normal neural tube morphogenesis (PubMed : 12091300, PubMed : 21115806). Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain (PubMed : 14648850, PubMed : 21115806). Functions with protocadherin pcdh19 to coordinate cell adhesion and cell movements during neurulation (PubMed : 21115806). pcdh19 shows little cell adhesion activity on its own but exhibits robust homophilic cell adhesion when in a complex with cdh2 and appears to mediate the adhesion while cdh2 acts as a cell adhesion cofactor in the complex (PubMed : 21115806, PubMed : 22184198, PubMed : 33004519). Contributes to neural progenitor cell patterning by promoting homophilic cell interactions (PubMed : 33004519). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). See full target information cdh2