Anti-NDUFS2 antibody,Abcam,AB216510

Host

Rabbit

Reactivity

Mouse

Application

WB

Platform ID

BAB085047187

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-NDUFS2 antibody
Cat. No.AB216510
HostRabbit
IsotypeIgG
ReactivityMouse
ApplicationWB
ClonalityPolyclonal
ImmunogenSynthetic Peptide within Human NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial aa 350-400 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed : 22036843, PubMed : 28031252, PubMed : 30922174). Essential for the catalytic activity of complex I (PubMed : 22036843, PubMed : 30922174). Essential for the assembly of complex I (By similarity). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (PubMed : 30922174). Plays an important role in carotid body sensing of hypoxia (By similarity). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity). See full target information NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

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