Anti-NGF antibody - BSA and Azide free,Abcam,AB6199
What is this antibody validated in? Anti-NGF antibody - BSA and Azide free (ab6199) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse samples. Trusted by the scientific community Anti-NGF - BSA and Azide free (ab6199) was first used in a scientific publication in 2000 and has been cited over 90 times in peer-reviewed journals. Reviewed by scientists Anti-NGF - BSA and Azide free (ab6199) has over 5 independent reviews from customers.
Host
Rabbit
Reactivity
Mouse, Human
Application
WB, ICC/IF
Platform ID
BAB213807881
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed : 14976160, PubMed : 20978020). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable) (PubMed : 20978020). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed : 20164177). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity). See full target information NGF
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