Anti-NKRF antibody,Abcam,AB168829

Target data Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed : 12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed : 12381793). Also involved in the regulation of IL-8 transcription (PubMed : 12381793). May also act as a DNA-binding transcription regulator : interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed : 10562553). See full target information NKRF