Anti-NLRP10 antibody - N-terminal,Abcam,AB198810

Target data Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed : 15096476). Displays anti-inflammatory activity (PubMed : 20393137). Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection (PubMed : 22672233). Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed : 28766990). Exhibits both ATPase and GTPase activities (PubMed : 23861819). See full target information NLRP10