Anti-NOTCH3 antibody [4HCLC],Abcam,AB277799
What are recombinant multiclonals? Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including: - The sensitivity of polyclonal antibodies by recognising multiple epitopes - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production View our range of recombinant multiclonal antibodies .
Host
Rabbit
Reactivity
Human
Application
WB
Platform ID
BAB529212736
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
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Product Specifications
Scientific Background
Specifications
NameAnti-NOTCH3 antibody [4HCLC]
Cat. No.AB277799
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationWB
ClonalityMulticlonal
Clone Number4HCLC
ImmunogenThis product was produced with the following immunogens:
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only
Scientific Background
Target data Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed : 15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). See full target information NOTC3_HUMAN
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