Anti-NOX5 antibody - C-terminal,Abcam,AB191010

Target data Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed : 12686516). Also synthesizes NAADP from its reduced NAADPH form which promotes Ca(2+) signaling during T cell activation (PubMed : 34784249). May play a role in cell growth and apoptosis (PubMed : 12686516).. Isoform v2. Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed : 11483596, PubMed : 14982937, PubMed : 17275676, PubMed : 17587483, PubMed : 21642394, PubMed : 22387196, PubMed : 22427510, PubMed : 24505490, PubMed : 36653838). Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contributes to endothelial response to thrombin (PubMed : 17275676). Regulates redox-dependent processes in lymphocytes and spermatozoa (PubMed : 11483596).. Isoform v1. Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor.. Isoform v5. This isoform lacks calcium-binding domains and was showed to present a NADPH oxidase activity in a calcium-independent manner (PubMed : 17275676, PubMed : 36653838). May be involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin (PubMed : 17275676). However another study showed an absence of oxidase activity (PubMed : 22427510). Subject to rapid degradation (PubMed : 36653838).. Isoform v3. Lacks calcium-dependent NADPH oxidase activity.. Isoform v4. Lacks calcium-dependent NADPH oxidase activity. See full target information NADPH oxidase 5