Anti-NUP98 antibody [2H10] - Nuclear Pore Marker,Abcam,AB50610

What is this antibody validated in? Anti-NUP98 antibody [2H10] - Nuclear Pore Marker (ab50610) is a rat monoclonal antibody and is validated for use in Western Blot (WB), Immunocytochemistry/immunofluorescence (ICC/IF) in African green monkey, Human, Mouse, Rat samples. Trusted by the scientific community Anti-NUP98 [2H10] - Nuclear Pore Marker (ab50610) was first used in a scientific publication in 2007 and has been cited over 20 times in peer-reviewed journals. Reviewed by scientists Anti-NUP98 [2H10] - Nuclear Pore Marker (ab50610) has over 5 independent reviews from customers. Other related products We have a range of other formats of antibody clone [2H10] also available for your convenience: ab50610, Carrier free - ab252256

Host

Rat

Reactivity

Mouse, Rat, Human, African green monkey

Application

WB, ICC/IF

Platform ID

BAB469829989

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-NUP98 antibody [2H10] - Nuclear Pore Marker
Cat. No.AB50610
HostRat
IsotypeIgG2c
ReactivityMouse, Rat, Human, African green monkey
ApplicationWB, ICC/IF
ClonalityMonoclonal
Clone Number2H10
ImmunogenRecombinant Fragment Protein within Human NUP98 aa 1-500. The exact immunogen used to generate this antibody is proprietary information.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed : 33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed : 28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed : 28221134).. (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed : 23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed : 23523133). See full target information NUP98

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.