Anti-Nanog antibody,Abcam,AB80892
What is this antibody validated in? Anti-Nanog antibody (ab80892) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC - Wmt), Immunocytochemistry/immunofluorescence (ICC/IF) in Mouse samples. Trusted by the scientific community Anti-Nanog (ab80892) was first used in a scientific publication in 2009 and has been cited over 360 times in peer-reviewed journals. Reviewed by scientists Anti-Nanog (ab80892) has over 15 independent reviews from customers.
Host
Rabbit
Reactivity
Mouse
Application
Flow Cyt, ICC/IF, ICC, WB, IHC - Wmt, IHC-P
Platform ID
BAB083048147
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal (PubMed : 25825768). Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (By similarity). Able to autorepress its expression in differentiating (ES) cells : binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. See full target information Nanog
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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