Anti-Nanog antibody,Abcam,AB21624
What is this antibody validated in? Anti-Nanog antibody (ab21624) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunocytochemistry/immunofluorescence (ICC/IF), ELISA in Human, samples. What is the molecular weight of Nanog? Anti-Nanog (ab21624) specifically detects a band for Nanog (UniProt: Q9H9S0) at a molecular weight of 34kDa. Trusted by the scientific community Anti-Nanog (ab21624) was first used in a scientific publication in 2005 and has been cited over 280 times in peer-reviewed journals. Reviewed by scientists Anti-Nanog (ab21624) has over 15 independent reviews from customers.
Host
Rabbit
Reactivity
Human
Application
sELISA, WB, ICC/IF
Platform ID
BAB145529406
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed : 25825768). Able to autorepress its expression in differentiating (ES) cells : binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. See full target information NANOG
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
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