Anti-Nectin 3 antibody [103-A1],Abcam,AB16913

Target data Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions (PubMed : 10744716, PubMed : 11827984, PubMed : 12121624, PubMed : 12558799, PubMed : 15328010, PubMed : 16128743, PubMed : 21798896). Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1 (PubMed : 16128743). Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation (PubMed : 16128743). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (PubMed : 15328010). Also involved in the formation of cell-cell junctions, including adherens junctions and synapses (PubMed : 11827984). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN1 : NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (PubMed : 21798896). Plays a role in the morphology of the ciliary body (PubMed : 15728677). See full target information Nectin3