Anti-Neurofilament heavy polypeptide antibody,Abcam,AB4680

Anti-Neurofilament heavy polypeptide antibody (ab4680) is a Chicken Polyclonal antibody and is validated for use in ICC, IHC-FrFl, WB. Anti-Neurofilament heavy polypeptide antibody (ab4680) has been cited over 135 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality validation processes ensure Anti-Neurofilament heavy polypeptide antibody (ab4680) has high sensitivity and specificity. Anti-Neurofilament heavy polypeptide antibody (ab4680) has 12 independent reviews from customers. Anti-Neurofilament heavy polypeptide antibody (ab4680) specifically detects Neurofilament heavy polypeptide (UniProt ID: P12036; Molecular weight: 112kDa) and is sold in 25 uL selling sizes. Neurofilament heavy polypeptide (NEFH, NFH) is a critical component of the neurofilament network, essential for maintaining the structural integrity and function of neurons. It plays a significant role in the radial growth of axons and the transmission of electrical impulses. Alterations in NEFH expression are associated with various neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Charcot-Marie-Tooth disease, and Alzheimer's disease (AD). Studying NEFH helps researchers understand the pathology of these conditions and the underlying neuronal dysfunction, highlighting its importance in the broader context of neurodegenerative disease research.

Host

Chicken

Reactivity

Mouse, Rat, Cow, Human

Application

WB, ICC, IHC-FrFl

Platform ID

BAB961883805

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Neurofilament heavy polypeptide antibody
Cat. No.AB4680
HostChicken
IsotypeIgY
ReactivityMouse, Rat, Cow, Human
ApplicationWB, ICC, IHC-FrFl
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.032% Sodium azide Constituents: PBS
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Neurofilaments usually contain three intermediate filament proteins : NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). See full target information NEFH

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