Anti-Neutrophil Elastase antibody,Abcam,AB68672
Product Specifications Anti-Neutrophil Elastase antibody (ab68672) is a rabbit polyclonal antibody and is validated for use in IHC-P in human, mouse samples. Anti-Neutrophil Elastase antibody (ab68672) specifically detects Neutrophil Elastase (UniProt ID: P08246; Molecular weight: 26kDa) and is sold in 100 µg selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-Neutrophil Elastase antibody (ab68672) has high sensitivity and specificity. Anti-Neutrophil Elastase antibody (ab68672) has been cited over 220 times in peer reviewed journals and is trusted by the scientific community. Anti-Neutrophil Elastase antibody (ab68672) has 18 independent reviews from customers.
Host
Rabbit
Reactivity
Mouse, Human
Application
IHC-P
Platform ID
BAB837520999
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (PubMed : 15140022). Promotes cleavage of GSDMB, thereby inhibiting pyroptosis (PubMed : 36899106). Promotes blood coagulation (PubMed : 20676107). Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG) (PubMed : 25211214, PubMed : 9111081). Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI) (PubMed : 20676107, PubMed : 25211214). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed : 10947984). See full target information ELANE
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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