Anti-Neutrophil Elastase antibody [EPR7479],Abcam,AB131260
What is this antibody validated in? Anti-Neutrophil Elastase antibody [EPR7479] (ab131260) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples. What is the molecular weight of Neutrophil Elastase? Anti-Neutrophil Elastase [EPR7479] (ab131260) specifically detects a band for Neutrophil Elastase (UniProt: P08246) at a molecular weight of 29kDa. Trusted by the scientific community Anti-Neutrophil Elastase [EPR7479] (ab131260) was first used in a scientific publication in 2012 and has been cited over 30 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Other related products We have a range of other formats of antibody clone [EPR7479] also available for your convenience: ab131260, Carrier free - ab219585 , PE - ab305680 , APC - ab305681 , HRP - ab305682 , Alkaline Phosphatase - ab308811 , Alexa Fluor® 647 - ab310127 , Alexa Fluor® 594 - ab310543 , Alexa Fluor® 555 - ab312073 , Alexa Fluor® 568 - ab312550 , Alexa Fluor® 488 - ab317069 Species reactivity Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human
Application
Flow Cyt (Intra), WB, ICC/IF, IHC-P
Platform ID
BAB650077222
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (PubMed : 15140022). Promotes cleavage of GSDMB, thereby inhibiting pyroptosis (PubMed : 36899106). Promotes blood coagulation (PubMed : 20676107). Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG) (PubMed : 25211214, PubMed : 9111081). Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI) (PubMed : 20676107, PubMed : 25211214). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed : 10947984). See full target information ELANE
Category Paths
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