Anti-Niemann Pick C1 Like 1/NPC1L1 antibody [EPR5717],Abcam,AB124801

Target data Plays a major role in cholesterol homeostasis (PubMed : 22095670). Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte (PubMed : 22095670). Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol (By similarity). Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia (PubMed : 15928087). May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation (PubMed : 15671032). May be involved in caveolin trafficking from the plasma membrane (By similarity). In addition, acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation (PubMed : 22095670). See full target information NPC1-like intracellular cholesterol transporter 1