Anti-Niemann Pick C1 antibody [EPR5209],Abcam,AB134113
Product Specifications Anti-Niemann Pick C1 antibody [EPR5209] (ab134113) is a rabbit recombinant monoclonal antibody and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, WB in human, mouse and rat samples. Anti-Niemann Pick C1 antibody [EPR5209] (ab134113) specifically detects Niemann Pick C1 (UniProt ID: O15118; Molecular weight: 140kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-Niemann Pick C1 antibody [EPR5209] (ab134113) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-Niemann Pick C1 antibody [EPR5209] (ab134113) has been confirmed by testing in knockout samples. Anti-Niemann Pick C1 antibody [EPR5209] (ab134113) has been cited over 51 times in peer reviewed journals and is trusted by the scientific community. Related Products Conjugation-ready, carrier free format available for antibody clone EPR5209 - ab224268 . Antibody clone EPR5209 is also available pre-conjugated to a variety of labels for your convenience - APC, PE, Alexa Fluor® 488, Alexa Fluor® 594, Alexa Fluor® 555, Alexa Fluor® 647, Alexa Fluor® 750 ( ab223985 , ab317903 , ab317983 , ab318025 , ab318067 , ab318108 , ab321075 ). Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
IHC-P, WB, Flow Cyt (Intra), ICC/IF
Platform ID
BAB151626478
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed : 10821832, PubMed : 12554680, PubMed : 18772377, PubMed : 27238017, PubMed : 9211849, PubMed : 9927649). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed : 18772377, PubMed : 19563754, PubMed : 27238017, PubMed : 27378690, PubMed : 28784760, PubMed : 9211849, PubMed : 9927649). Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (PubMed : 19563754). Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9 (PubMed : 28336668).. (Microbial infection) Acts as an endosomal entry receptor for ebolavirus. See full target information NPC intracellular cholesterol transporter 1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
- Products>Trial Size Antibodies
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