Anti-Ninein/NIN antibody - Centrosome Marker,Abcam,AB4447

The centrosomal protein ninein has been identified as a microtubule minus end capping and centriole anchoring protein, but its true physiological function remains to be determined. At mitosis, ninein has been observed in association with the mitotic spindle as well as at the centrosomes.

Host

Rabbit

Reactivity

Human

Application

ICC/IF

Platform ID

BAB776738924

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Ninein/NIN antibody - Centrosome Marker
Cat. No.AB4447
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationICC/IF
ClonalityPolyclonal
Concentration0.9 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed : 15190203, PubMed : 23386061). May also act as a centrosome maturation factor (PubMed : 11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed : 15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed : 15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed : 23386061). See full target information NIN

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