Anti-Nkx2.5 antibody,Abcam,AB272914

Host

Rabbit

Reactivity

Mouse, Rat

Application

WB, IHC-P

Platform ID

BAB339869871

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Nkx2.5 antibody
Cat. No.AB272914
HostRabbit
IsotypeIgG
ReactivityMouse, Rat
ApplicationWB, IHC-P
ClonalityPolyclonal
Concentration0.9 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Mouse Nkx2-5. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Transcription factor required for the development of the heart and the spleen (PubMed : 16556915, PubMed : 19483677, PubMed : 22560297, PubMed : 9584153). During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (PubMed : 9584153). May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (PubMed : 12023302). Binds to the core DNA motif of NPPA promoter (PubMed : 19483677). Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (PubMed : 22560297). Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia (By similarity). See full target information Nkx2-5

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