Anti-Noxa antibody [114C307],Abcam,AB13654

What is this antibody validated in? Anti-Noxa antibody [114C307] (ab13654) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P) in Human, Mouse samples. Trusted by the scientific community Anti-Noxa [114C307] (ab13654) was first used in a scientific publication in 2004 and has been cited over 90 times in peer-reviewed journals. Reviewed by scientists Anti-Noxa [114C307] (ab13654) has over 5 independent reviews from customers.

Host

Mouse

Reactivity

Mouse, Human

Application

IHC-P, Flow Cyt (Intra), WB

Platform ID

BAB716956369

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Noxa antibody [114C307]
Cat. No.AB13654
HostMouse
IsotypeIgG1
ReactivityMouse, Human
ApplicationIHC-P, Flow Cyt (Intra), WB
ClonalityMonoclonal
Clone Number114C307
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Protein within Human PMAIP1. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. See full target information PMAIP1

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