Anti-Noxa antibody [ABM46B8],Abcam,AB220177
Host
Rat
Reactivity
Human
Application
WB
Platform ID
BAB654475110
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
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Product Specifications
Scientific Background
Specifications
NameAnti-Noxa antibody [ABM46B8]
Cat. No.AB220177
HostRat
IsotypeIgG2b
ReactivityHuman
ApplicationWB
ClonalityMonoclonal
Clone NumberABM46B8
Concentration0.5 mg/mL Batch dependent concentration
ImmunogenRecombinant Full Length Protein corresponding to Mouse Pmaip1.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only
Scientific Background
Target data Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. See full target information PMAIP1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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