Anti-Noxa antibody [S07-3H6],Abcam,AB317420
Host
Rabbit
Reactivity
Human
Application
WB
Platform ID
BAB966981357
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
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Product Specifications
Scientific Background
Specifications
NameAnti-Noxa antibody [S07-3H6]
Cat. No.AB317420
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationWB
ClonalityMonoclonal
Clone NumberS07-3H6
ImmunogenSynthetic Peptide within Human PMAIP1.
PurityAffinity purification
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.01% Sodium azide Constituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only
Scientific Background
Target data Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. See full target information PMAIP1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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